Cerebral Oxygenation and Neurological Outcomes Following Critical Illness
CONFOCAL-2
1
PURPOSE
The study aims to determine whether low brain oxygen levels are associated with delirium and poor neurological recovery in critically ill patients. It also seeks to identify novel blood biomarkers that could predict brain injury and cognitive decline.
2
PROGRESS
55
500
patients enrolled
(as of Sept. 2025)
3
FUTURE
Findings from CONFOCAL-2 may lead to improved bedside monitoring tools and personalized care strategies for ICU patients. Ultimately, the study hopes to reduce long-term cognitive complications and improve recovery outcomes after critical illness.
What is CONFOCAL-2?
CONFOCAL-2 is a multicentre observational study examining the link between cerebral oxygenation and delirium in ICU patients with respiratory failure or shock. It uses near-infrared spectroscopy and blood biomarkers to explore brain function during critical illness.
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Why is this important?
Delirium affects up to 80% of ICU patients and is linked to long-term cognitive impairment and reduced quality of life. Understanding its physiological and biochemical causes could lead to better monitoring, prevention, and treatment strategies.
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What is involved in the study?
Led by Dr. J. Gordon Boyd, the research team coordinates data collection, analysis, and follow-up across multiple Canadian and U.S. sites. They also manage ethical oversight, patient recruitment, data capture using FORE-SIGHT monitor, and advanced neurocognitive assessments.
