Fluids in Septic Shock
FISSH
1
PURPOSE
The purpose of the FISSH study is to determine whether Ringer’s Lactate, a balanced fluid with lower chloride content, improves survival and reduces complications compared to normal saline in septic shock patients. It also explores biological markers like cell-free DNA to understand underlying mechanisms.
2
PROGRESS
21
1096
patients enrolled
(as of Sept. 2025)
3
FUTURE
Results from FISSH will help shape fluid resuscitation guidelines for septic shock worldwide. If Ringer’s Lactate proves superior, it could lead to a major shift in ICU fluid management, improving survival rates and reducing organ failure in critically ill patients.
What is FISSH?
The FISSH study investigates whether using Ringer’s Lactate instead of normal saline improves outcomes in patients with septic shock. It is a multi-center, blinded randomized controlled trial focused on 30-day mortality and other critical care measures.
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Why is this important?
Septic shock has a high mortality rate, and fluid choice during resuscitation may significantly impact patient outcomes. Despite potential harms of high-chloride fluids like saline, they remain widely used, and this study provides urgently needed direct evidence to inform practice.
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Study Arms:
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CONTROL
INTERVENTION
